Colombia and Uruguay provide the stage for some heavyweight battles this weekend, while underdogs set out to clinch critical wins in Italy and Spain. takes a closer look at some of the top games in Round 22 of FIFA World Leagues Predictor.

Match of the week
Tolima-Junior (Colombia)
On aggregate, Tolima and Junior were the two best performing clubs in Colombia's 2009 Copa Mustang. However, both sides failed in their attempts to claim either of the two seasonal championships. This time out, Junior are considered underdogs in Ibague (83 points), while a repeat of their 2009 Apertura encounter (Tolima 1-0 Junior) would return backers 35 points.

The longshot
Napoli-Inter Milan (Italy)
With a nine-point lead over their closest rivals, Internazionale are poised to clutch a fifth consecutive Serie A championship. This weekend, Inter travel to fourth-placed Napoli. The southern outfit have been enjoying a fine season after almost two decades of disappointment and are in contention for a coveted top-three finish. Napoli are also undefeated in their 11 home games this season, making this an awkward result to predict.

Relegation rumble
Real Valladolid-Real Zaragoza (Spain)
Real Valladolid have the chance to move out of the relegation places in front of a home crowd. Opponents Real Zaragoza are treading water just outside the drop zone and will be eager to keep their hosts directly below them. They will, however, need to overcome a poor away record that has seen them rack up four losses in their last last five away fixtures.

Valuable points
Cartagines-UCR (Costa Rica)
Cartagines have drawn all four of their opening games of the 2010 Primera A season. The Invierno 2009 quarter-finalists are in need of a win if they aim to make this year's play-offs. By contrast, UCR have had an erratic start to the season, with one win, one draw and two losses. A fifth Cartagines draw or a UCR upset offer the highest returns while a home win is roughly half as valuable.

The undefeated
Liverpool-Nacional (Uruguay)
The 2009 Apertura’s top two finishers meet once again in Uruguay’s latest Clausura season. The rivals met only once in league competition last year, with Nacional enjoying a 2-1 win at home. Both teams finished the Apertura undefeated at home, an advantage Liverpool will be hoping to make the most of this time round.