After another thrilling instalment of mid-week European action, turns the spotlight back to domestic action this weekend as the race for the various national titles hots up.

Of the big names topping their league standings, Barcelona, Inter Milan and Marseille all have away assignments this weekend, while defeats for fellow continental heavyweights Lyon, Bayern Munich and Real Madrid on their respective visits to Bordeaux, Arminia Bielefeld and Recreativo de Huelva would distance them still further from top spot. Over in England, three of the country's established big four will be excused Premier League duty as they bid to win a place in the FA Cup final.

Premier League: Relegation battles to the fore
On the back of their hard-fought midweek UEFA Champions League encounters, three of England's big four will continue in knockout mode this weekend. Arsenal and Chelsea meet in the semi-finals of the FA Cup, with the winners taking on either Everton or Manchester United in the showpiece finale. As a result, the 33rd matchday of the Premier League will not conclude until next week, with Liverpool (2nd) taking on Arsenal (4th) on Tuesday before Chelsea (3rd) face Everton (6th) and leaders United welcome Portsmouth (14th) the following day.

In the meantime, relegation issues will come to the fore this weekend with 18th-placed Newcastle United travelling to Tottenham Hotspur (9th), Middlesbrough (19th) hosting Fulham (8th) and genuine 'six-pointers' between Sunderland (17th) and Hull City (15th), and Stoke City (13th) and Blackburn Rovers (16th).

The question: Can Aston Villa end a run of ten games without a win in all competitions when they host West Ham United?
The big game: Tottenham-Newcastle United, Sunday 19 April, 13.30 CET, White Hart Lane
The quote: "Our supporters have helped make our home ground into a fortress, but Newcastle are fighting for their lives. So we have a very difficult match ahead of us," Spurs defender Ledley King.

La Liga: Barcelona in Madrid dry-run
Catalan giants Barça may be in a position to safeguard the title in a fortnight's time at the Estadio Santiago Bernabeu, and this weekend's visit to 14th-placed Getafe on the outskirts of the Spanish capital could be the perfect dress rehearsal. Real Madrid, for their part, will be aiming for all three points away to relegation threatened Recreativo (18th) while hoping their neighbours can trip up the Blaugranas.

Twelve points behind Madrid are Sevilla, who themselves currently hold a comfortable eight-point lead over fourth-placed Valencia - their opponents this weekend. A win for the Andalusians would all but seal their place in the top three, though Los Chés are on a fine run of form and will be confident of a victory on home soil. Lurking just behind the Mestalla outfit in the standings are Villarreal (5th), Atletico de Madrid (6th) and Malaga (7th), who take on Valladolid (9th), Numancia (19th) and Mallorca (12th) respectively.

The question: Given his side are still competing on three fronts (La Liga, Copa del Rey and UEFA Champions League), will Pep Guardiola rotate his squad against Getafe?
The big game: Valencia-Sevilla, Sunday 19 April, 19.00 CET, Estadio Mestalla.
The quote: "It's vital we beat Numancia. The time for talking is over, it's time to act and show that the team wants to qualify for the Champions League and be among the best," Atletico Madrid's Colombian defender Luis Perea.

Bundesliga: Magath-Klinsmann struggle continues
Having enjoyed immense popularity prior to taking the Bayern Munich reins, former Bayern and Germany striker Jurgen Klinsmann's position as coach is becoming less secure by the day. Since the humiliating 5-1 defeat at Wolfsburg on 4 April, the sword of Damocles has hung over Klinsi's head, and this weekend's clash at relegation-threatened Arminia Bielefeld (15th) will be no different. Felix Magath, at the helm of on-fire league leaders Wolfsburg, has amply avenged his ignominious exit from Munich in 2007 and will be aiming to guide his side to their tenth consecutive victory at home to Bayer Leverkusen (9th).

Among the other title contenders, Hamburg (3rd) and Stuttgart (5th) face testing trips to Hannover (13th) and Cologne (11th) respectively, while former leaders Hertha Berlin (4th), on a run of three defeats in a row and denied the services of Andriy Voronin, host a Werder Bremen (10th) side who beat them 5-1 earlier in the season.

The question: Can Schalke win their third consecutive match since coach Fred Rutten's dismissal when they host Energie Cottbus on Friday?
The big game: Wolfsburg-Leverkusen, Saturday 18 April, 15.30, VW-Arena
The quote: "Now that Bayern are no longer involved in the Champions League, they've got no grounds for dropping any more points in the league," Wolfsburg coach Felix Magath.

Serie A: Inter out to end Juve's hopes
Holding a ten-point lead over closest challengers Juventus with seven matchdays to go, Inter Milan are well on course to pick up a fourth league title in a row. However, that could change should the Bianconeri beat Jose Mourinho's men this weekend in Turin.

Further down the standings and the battle for the third available Champions League qualifying berth rages on, with just six points separating third-placed AC Milan from Fiorentina in 5th. While David Beckham and Co take on Torino (17th) at the San Siro and the Viola visit Udinese (13th), on-form Genoa in fourth are set to host Lazio (9th).

The question: Will Genoa pick up their fifth Serie A win in a row when they meet Lazio?
The big game: Juventus-Inter Milan, Saturday 18 April, 20.30 CET, Stadio Olimpico.
The quote: "A nine-point gap from Inter doesn't mean that the championship race is over. It's our duty to keep on dreaming," Juventus attacker Sebastian Giovinco.

Ligue 1: Lyon under pressure
Overtaken at the top by Marseille last week, seven-time French champions Lyon (2nd) will be keen to pick up a positive result away to Bordeaux (3rd) this weekend. Les Girondins, for their part, who are just a point behind Les Gones and two adrift of leaders L'OM, know a win would be a huge boost for their own title hopes.

Marseille, meanwhile, will be determined to strengthen their hold on top spot when they visit mid-table Lorient, while Paris Saint-Germain (6th) would love to get back on the victory trail against bottom side Le Havre. Toulouse (4th) and Lille (5th), who are both level on points with PSG and just five adrift of the leaders, visit Grenoble (14th) and Saint-Etienne (19th) respectively.

The question: On a run of four wins in a row, can L'OM make it five against Lorient?
The big match: Bordeaux-Lyon, Sunday 19 April, 21.00 CET, Stade Chaban-Delmas
The quote: "I don't understand how we can be humiliated by the league's bottom side and yet perform so well away against the leaders," Monaco goalkeeper Stephane Ruffier, after the 2-2 draw at Lyon on 12 April.

Over in the Netherlands, we have the unusual situation of a Klassieker between PSV Eindhoven and Ajax that is unlikely to affect the title race. Reigning champions PSV are languishing back in fifth while third-placed Ajax, despite a ten-match unbeaten run, appear too far behind AZ Alkmaar to deny Louis Van Gaal's men only their second Eredivisie crown. That said, both sides would love to win the 100th edition of this classic encounter and give their supporters some much-needed cheer.

In Scotland, meanwhile, Celtic - one point clear of Rangers - will hope to stretch their lead over their eternal rivals with victory over Aberdeen before Walter Smith takes his side to Edinburgh to face a revitalised Hibernian.