Neymar set to feature against USA
Coach Mano Menezes has not confirmed the starting XI, but the Santos forward - who missed the win against Denmark last Saturday - should be part of the team, replacing Lucas, with goalkeeper Rafael in for Jefferson.
"I will keep most of the group that beat Denmark, but I will make small changes as I want to see other players," said Menezes, who will face the same opponents as in his national team debut, a 2-0 win in August 2010. "The target is to keep up the same good level we showed last Saturday."
Menezes has chosen a host of under-23 players as he focuses on preparing the team for the Men's Olympic Football Tournament London 2012.
After Wednesday's match they will face Canada before making their 2014 qualifying bow on 8 June facing Antigua and Barbuda. Their campaign continues four days later against Guatemala.
"We want to play football, in every match we work to leave the long balls behind," said coach Juergen Klinsmann.
The former world champion's side thrashed Scotland 5-1 last time out with a hat-trick from Landon Donovan.
"In that game we managed to impose our rhythm," said Klinsmann. "Midfielders made good combinations and the forwards had an outstanding performance.
"We want to improve in every aspect that we're working on, and see what our real level is against one of the best teams in the world. We're making big progress."