Belarus tighten grip on second
Sergey Kornilenko fired the hosts ahead from the penalty spot after 48 minutes and Anton Putsila secured the three points with his side's second inside the final 20 minutes.
The result lifts Belarus onto 12 points after seven games, just one point behind group leaders France who have a game in hand. Luxembourg remain bottom of the pile with just one point from seven games.
Belarus were slow out of the blocks and failed to break down the visitors' defence until close to the half-hour mark when Putsila hit a rising shot over the bar.
The two sides reached the interval with the scoreline blank, although it took just three minutes of the second period for the hosts to make the breakthrough.
Luxembourg defender Eric Hoffmann was the offender as he handled in his own penalty area, and Kornilenko, who spent part of last season on loan at Blackpool from Zenit St Petersburg, scored from 12 yards.
Still the visitors would not be overawed, and threatened three times through Dimitri Kitenge in the second period as Belarus continued to look unconvincing in all areas of the park.
However, the result was finally put beyond a doubt in the 73rd minute when Putsila picked up the ball in the area and lashed home a fierce left-footed drive into the roof of the net.