Injury rules Balotelli out
Enrico Castellacci, Italy's team doctor, said he wouldn't be fit in time after hurting the same knee he has already been operated on.
"It's the operated knee. I'm worried and I'll be getting straight in contact with the medical staff at Manchester City," said Castellacci.
Italy have a comfortable lead at the top of Group C and should they win on Friday would need only two wins from their final four games to book their passage to the European Championships in Poland and Ukraine next year.