Hoffenheim suffer Wiese blow
The 30-year-old damaged ligaments in his right knee in the last training session before Sunday's game in Sinsheim.
Tests on Saturday evening revealed the injury, which is expected to keep him out until just before next month's winter break.
Belgian goalkeeper Koen Casteels will take over in the Hoffenheim goal against Leverkusen.
Wiese made the last of his six appearances for Germany in the 2-1 win over France in Bremen in February.