Dario Lezcano put Lucerne in front after 18 minutes and again 21 minutes into the second half after Alexander Frei's equaliser. However, Marco Streller had the final say, scoring Basel's second nine minutes from time.
Newly-promoted St Gallen joined Basel in taking four points from their opening two fixtures with a 1-0 win at Lausanne. Ezequiel Scarione grabbed the only goal shortly before the half-hour mark.
