Al Shabab opened their Saudi League campaign with a disappointing 2-0 defeat at the hands of minnows Al Raed.
The hosts, who will meet Korea Republic's Jeonbuk Hyundai Motors in the quarter-finals of the Asian Champions League next month, fell behind after 11 minutes as Mousa Salman Al Shammari fired home from the penalty spot.
Al Shabab went on the attack in the second half but were stunned by a second goal for Al Raed as Mazen Al Faraj struck in the second minute of stoppage time.
Last year's runners-up Al Ittihad edged Al Ittifaq 2-1 with all three goals coming in the second half.
Naif Hazzazi opened the scoring for Al Ittihad five minutes after the hour mark before Algerian striker Abdulmalik Ziaya doubled their advantage with 12 minutes remaining.
Al Ittifaq reduced the deficit with four minutes left on the clock through striker Sebastian Tagliabue but his goal was not enough as Al Ittihad held on for the three points.
Elsewhere, Al Nassr needed a late goal from Romanian midfielder Ovidiu Petre to beat lowly Najran 1-0 while Al Qadisiya eased to a 3-1 win over Al Fateh.
