Donovan returns to Klinsmann's "A" team after 10 matches out having enjoyed a stellar CONCACAF Gold Cup campaign in July.
Also included in the squad are young dual-nationals John Anthony Brooks and Aron Johannsson, both in their first FIFA World Cup qualifying call-ups.
Johansson, a former Icelandic youth international, is committed to the USA after completing a one-time switch.
Hertha Berlin defender Brooks has represented Germany at youth level.
The United States top the table in the six-nation final qualifying group in North and Central America with 13 points. Costa Rica are second on 11 points, and have never lost to the USA at home in a qualifier.
"The Costa Rica game in San Jose is the biggest game in 2013 for all of us because we want to win there," said Klinsmann. "We want to qualify as soon as possible for the World Cup in Brazil. We want to get the first ever three points in World Cup qualifying in Costa Rica."
US captain Clint Dempsey is poised to earn his 100th cap.
Goalkeepers: Brad Guzan (Aston Villa/England), Tim Howard (Everton/England), Nick Rimando (Real Salt Lake)
Defenders: DaMarcus Beasley (Puebla/Mexico), Matt Besler (Sporting Kansas City) John Brooks (Hertha Berlin/Germany), Geoff Cameron (Stoke City/England), Edgar Castillo (Tijuana/Mexico), Brad Evans (Seattle Sounders), Omar Gonzalez (LA Galaxy), Michael Orozco (Puebla/Mexico)
Midfielders: Kyle Beckerman (Real Salt Lake), Alejandro Bedoya (Nantes/France), Michael Bradley (Roma/Italy), Mix Diskerud (Rosenborg/Norway), Fabian Johnson (Hoffenheim/Germany), Jermaine Jones (Schalke/Germany), Graham Zusi (Sporting Kansas City)