A strong USA side took the lead in Guatemala City when Fulham midfielder Clint Dempsey converted Fabian Johnson's pass five minutes before half-time. But they failed to add to that advantage and home substitute Marco Papa nicked a point for his side with an 83rd-minute free-kick.
The USA now have four points from their first two matches, with Guatemala just getting off the mark. Meanwhile, Jamaica also have four points after fighting out a goalless draw with Antigua and Barbuda in St John's.
Mexico made it two wins from two with a 2-1 victory over El Salvador in Group B. El Tri took the lead through Jesus Zavala after an hour's play in San Salvador, but were pegged back just five minutes later when Alfredo Pacheco netted a free-kick the hosts. With 82 minutes gone, though, Hector Moreno headed home the winner.
Costa Rica moved second in the group with a 4-0 win in Guyana. Alvaro Saborio grabbed a hat-trick, scoring in 20th, 26th and 52nd minutes, while Joel Campbell completed the scoring with 13 minutes remaining.
"It was a very important match to us. I saw a united group that played good football and knew how to take a solid win," said Costa Rica coach Jorge-Luis Pinto. "You can be sure the team will improve to get the competitive form they need to reach Brazil 2014."
In Group C, Panama claimed their second win with a 1-0 success over Cuba. Nelson Barahona netted the winner in the 58th minute to put the Panamanians two points clear at the summit after Canada's surprise 0-0 draw against Honduras in Toronto.