"Botswana is a local derby. Most of their players play in South Africa and against them, the attitude and the emotions will be the key factors,” Pitso Mosimane, South Africa coach.
Previous FIFA World Cup hosts South Africa will be pleased with their draw in Group A of African qualifying, but nevertheless will face strong challenges from Botswana and Central African Republic.
Former champions Ismaili claimed a 1-0 win away to Sudan's Al Hilal, but fellow Egyptian side Al Ahly fell 2-0 to Ittihad in the first leg of the third round.
Malawi, Mozambique, Rwanda and Sudan are among the teams through to the final round of CAF qualifying, but Senegal and Congo DR are out.
Senegal were the only major side to fall as Round Three of the African qualifiers for the 2010 FIFA World Cup South Africa entered the final straight.
With so many places still up for grabs and a plethora of potential outcomes, FIFA.com takes you through the possible scenarios group-by-group.
