Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Despite Niko Kranjcar's winner against Kazakhstan, Croatia were left to count the cost of two defeats to England as they failed to qualify for South Africa.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.
Belarus completed their home fixtures in 2010 FIFA World Cup South Africa qualifying Group 6 with a comprehensive defeat of Kazakhstan in Brest.
Kazakhstan completed the double over Andorra tonight with a 3-1 win in Andorra La Vella in Group 6 of the European qualifying zone.