Goals from Jozy Altidore and Clint Dempsey gave the US a 2-1 come-from-behind win over Turkey as the team prepare to depart for South Africa.
Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Fatih Terim's second reign as Turkey boss came to an end with a comfortable, if unspectacular, ten-man victory over Group 5's basement side Armenia.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.
Belgium moved to within two points of Turkey in Group 5 with an Emile Mpenza-inspired 2-0 win over the Turks in Brussels.