Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Romania ended their disappointing South Africa 2010 qualifying campaign with a 3-1 home victory over Group 7's bottom team, the Faroe Islands.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.
Serbia booked their place at the 2010 FIFA World Cup South Africa with a superb 5-0 win over Romania in which Milan Javanovic scored a brace.
Ten tickets to South Africa remain up for grabs in Europe, where crucial games are set to unfold in Athens, Copenhagen, Dublin, Lisbon and Moscow.