Malawi, Mozambique, Rwanda and Sudan are among the teams through to the final round of CAF qualifying, but Senegal and Congo DR are out.
Senegal were the only major side to fall as Round Three of the African qualifiers for the 2010 FIFA World Cup South Africa entered the final straight.
Argentina-Uruguay is the most enticing clash of this weekend's qualifiers, according to you, the FIFA.com users, in our most recent online poll.
With so many places still up for grabs and a plethora of potential outcomes, FIFA.com takes you through the possible scenarios group-by-group.
The crucial South Africa 2010 qualifier with Côte d'Ivoire has caused former Madagascar captain Mamisoa Razafindrakoto to come out of retirement.
The injured Didier Drogba will again miss out for Côte d'Ivoire, who look set to partner Salomon Kalou and Bakary Kone in attack aganist Madagascar.