Honduras beat Mexico on Wednesday, a result which sends both sides through at the expense of Jamaica. T&T join them in the last six.
Wednesday will see a dramatic finale in CONCACAF as Mexico, Honduras, Jamaica, T&T and Guatemala chase places in the final round.
A surprise 2-1 defeat at the hands of Cuba has left the Guatemalans' hopes of progressing to the final qualifying round hanging by a thread.
Mexico, Jamaica and Honduras are all still alive with a game to go in Group 2, while El Salvador booked their passage and T&T are nearly there.
Reinhold Fanz has left his post as Cuba boss after a 6-1 loss to the USA put the islanders out of the hunt for a place at South Africa 2010.
While Costa Rica and the USA cool their jets with passage assured, Mexico face a tricky qualifying test in the Great White North in midweek.