Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Switzerland drew 0-0 at home to Israel to bank top spot in Group 2 and qualification for next year's FIFA World Cup at the expense of Greece.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.
Elyaniv Barda scored a double as Israel kept alive their slim hopes of qualifying for South Africa 2010 with a 3-1 win over Moldova.
Ten tickets to South Africa remain up for grabs in Europe, where crucial games are set to unfold in Athens, Copenhagen, Dublin, Lisbon and Moscow.