The majority of sides expected to qualify for South Africa 2010 from Europe did so, although notable European absentees include Russia and Croatia.
Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Switzerland drew 0-0 at home to Israel to bank top spot in Group 2 and qualification for next year's FIFA World Cup at the expense of Greece.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.
Philippe Senderos scored twice in as many minutes as Switzerland cruised to a 3-0 win over Luxembourg that keeps alive their South Africa 2010 hopes.