Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Olof Mellberg scored twice as Sweden won their final South Africa 2010 qualifier, but events elsewhere meant their bid for qualification reached its end.
Sweden coach Lars Lagerback has admitted that the team are likely to benefit from a "fresh start"once the South Africa 2010 qualifiers are over.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.
Former European champions Denmark secured automatic qualification for the 2010 FIFA World Cup South Africa finals after beating Sweden 1-0.