Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Slovakia won 1-0 away to Poland to secure first place in Group 3 and a berth at the FIFA World Cup for the first time since gaining independence.
FIFA.com catches up with goalkeeper Jan Mucha to discuss the biggest match in Slovakia's history in Poland, the nation he has called home since 2005.
Slovakia captain Robert Vittek has vowed that "qualification will be ours" after suffering a setback in their South Africa 2010 bid against Slovenia.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.