Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Portugal cruised to a 4-0 victory over Malta that clinched them a place in the play-offs and ended Sweden's chances of reaching South Africa 2010.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Due to an ankle injury, Real Madrid striker Cristiano Ronaldo will not be fit to play in Portugal's final South Africa 2010 qualifier against Malta on Wednesday.
Despite boasting the reigning FIFA World Player Cristiano Ronaldo among other talents, Portugal face an uphill struggle to reach South Africa 2010.
A late Ian Azzopardi own goal grabbed Sweden a 1-0 success away to tailenders Malta that lifted their hopes of advancing from a competitive pool.