Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Greece secured their place in the FIFA World Cup qualifying play-offs with a comfortable 2-1 defeat of Luxembourg in the Olympic Stadium in Athens.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.
Philippe Senderos scored twice in as many minutes as Switzerland cruised to a 3-0 win over Luxembourg that keeps alive their South Africa 2010 hopes.
Ten tickets to South Africa remain up for grabs in Europe, where crucial games are set to unfold in Athens, Copenhagen, Dublin, Lisbon and Moscow.