Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Two goals from Andrejs Rubins helped Latvia finish their South Africa 2010 qualifying campaign with a 3-2 home win over ten-man Moldova.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.
Ten tickets to South Africa remain up for grabs in Europe, where crucial games are set to unfold in Athens, Copenhagen, Dublin, Lisbon and Moscow.
FIFA.com looks at the career of Latvian veteran Vitalijs Astafjevs, who proudly stands on the verge of becoming the most-capped European in history.