Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Estonia rounded off their Group 5 campaign in style, cruising to a comfortable 2-0 win over Dick Advocaat's lacklustre Belgium side.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.
Goals from Edin Dzeko and Vedad Ibisevic ensured Bosnia-Herzegovina will finish second in Group 5 and progress to the play-offs for a place in South Africa.
Ten tickets to South Africa remain up for grabs in Europe, where crucial games are set to unfold in Athens, Copenhagen, Dublin, Lisbon and Moscow.