Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Fatih Terim's second reign as Turkey boss came to an end with a comfortable, if unspectacular, ten-man victory over Group 5's basement side Armenia.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.
Spain coach Vicente del Bosque praised his side after seeing them come out on top in what he admits was a "difficult" qualifier against Armenia.
A second-half penalty from Juan Mata gave Spain a hard-fought 2-1 win in Armenia and maintained La Roja's 100 per cent record in 2010 qualifying.