Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Olof Mellberg scored twice as Sweden won their final South Africa 2010 qualifier, but events elsewhere meant their bid for qualification reached its end.
Sweden coach Lars Lagerback has admitted that the team are likely to benefit from a "fresh start"once the South Africa 2010 qualifiers are over.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Despite boasting the reigning FIFA World Player Cristiano Ronaldo among other talents, Portugal face an uphill struggle to reach South Africa 2010.
Denmark's lead in European qualifying Group 1 was cut to two points after a disappointing draw with Albania in Tirana.