Switzerland and Slovakia seized Europe's last two automatic berths in South Africa, while Portugal, Greece, Slovenia and Ukraine made the play-offs.
Two goals from Andrejs Rubins helped Latvia finish their South Africa 2010 qualifying campaign with a 3-2 home win over ten-man Moldova.
Switzerland drew 0-0 at home to Israel to bank top spot in Group 2 and qualification for next year's FIFA World Cup at the expense of Greece.
Greece secured their place in the FIFA World Cup qualifying play-offs with a comfortable 2-1 defeat of Luxembourg in the Olympic Stadium in Athens.
Switzerland, Greece, Slovakia and Slovenia head into Wednesday's final qualifiers hoping to claim the two remaining direct tickets to South Africa.
Italy, Germany, Denmark and Serbia all sealed their places at South Africa 2010 with positive results during Saturday's nervy round of qualifiers.