Malawi, Mozambique, Rwanda and Sudan are among the teams through to the final round of CAF qualifying, but Senegal and Congo DR are out.
There were celebrations for three teams in African qualifying on Sunday, as Burkina Faso, Egypt and Guinea all secured first place in their groups.
With so many places still up for grabs and a plethora of potential outcomes, FIFA.com takes you through the possible scenarios group-by-group.
FIFA has decided against all games on the final matchday of the African Zone qualifying for South Africa 2010 kicking off simultaneously.
In the latest FIFA World Cup qualifying action in Africa,
Ghana and Guinea each moved to the top of their respective group
after winning at home.
Côte d'Ivoire and Tunisia are two of the teams aiming to get their stuttering South Africa 2010 qualifying bids back on track this weekend.