Malawi, Mozambique, Rwanda and Sudan are among the teams through to the final round of CAF qualifying, but Senegal and Congo DR are out.
Senegal were the only major side to fall as Round Three of the African qualifiers for the 2010 FIFA World Cup South Africa entered the final straight.
Emmanuel Adebayor ended a one-month national team boycott by scoring four goals as Togo sank Swaziland 6-0 in a 2010 FIFA World Cup qualifier.
With so many places still up for grabs and a plethora of potential outcomes, FIFA.com takes you through the possible scenarios group-by-group.
Dennis Mesina is in optimistic mood as Swaziland go in search of a win over Togo that would send them through to the final phase of African qualifying.
FIFA has decided against all games on the final matchday of the African Zone qualifying for South Africa 2010 kicking off simultaneously.