Malawi, Mozambique, Rwanda and Sudan are among the teams through to the final round of CAF qualifying, but Senegal and Congo DR are out.
Senegal were the only major side to fall as Round Three of the African qualifiers for the 2010 FIFA World Cup South Africa entered the final straight.
With so many places still up for grabs and a plethora of potential outcomes, FIFA.com takes you through the possible scenarios group-by-group.
FIFA has decided against all games on the final matchday of the African Zone qualifying for South Africa 2010 kicking off simultaneously.
In the South Africa 2010 qualifiers in Africa today, Ghana
fell to Gabon, Côte d'Ivoire were held by Botswana and South
Africa lost to Sierra Leone.
Côte d'Ivoire and Tunisia are two of the teams aiming to get their stuttering South Africa 2010 qualifying bids back on track this weekend.