Malawi, Mozambique, Rwanda and Sudan are among the teams through to the final round of CAF qualifying, but Senegal and Congo DR are out.
Senegal were the only major side to fall as Round Three of the African qualifiers for the 2010 FIFA World Cup South Africa entered the final straight.
With so many places still up for grabs and a plethora of potential outcomes, FIFA.com takes you through the possible scenarios group-by-group.
FIFA.com hears from Bordeaux's Moroccan striker Marouane Chamakh, who's eager to play his part in the Atlas Lions' South Africa 2010 bid.
FIFA has decided against all games on the final matchday of the African Zone qualifying for South Africa 2010 kicking off simultaneously.
In the latest FIFA World Cup qualifying action in Africa,
Ghana and Guinea each moved to the top of their respective group
after winning at home.