Malawi, Mozambique, Rwanda and Sudan are among the teams through to the final round of CAF qualifying, but Senegal and Congo DR are out.
Senegal were the only major side to fall as Round Three of the African qualifiers for the 2010 FIFA World Cup South Africa entered the final straight.
Six years on from their FIFA World Cup heroics in the Far East, Senegal are struggling to qualify for South Africa 2010 and must beat Gambia.
With so many places still up for grabs and a plethora of potential outcomes, FIFA.com takes you through the possible scenarios group-by-group.
With 17 places in the next round up for grabs on the final weekend of the first group phase, FIFA.com previews the action in Groups 1-6.
FIFA has decided against all games on the final matchday of the African Zone qualifying for South Africa 2010 kicking off simultaneously.