Malawi, Mozambique, Rwanda and Sudan are among the teams through to the final round of CAF qualifying, but Senegal and Congo DR are out.
Senegal were the only major side to fall as Round Three of the African qualifiers for the 2010 FIFA World Cup South Africa entered the final straight.
With so many places still up for grabs and a plethora of potential outcomes, FIFA.com takes you through the possible scenarios group-by-group.
Chris Malonga and Francky Sembolo have returned to the Congo squad for next week's crucial FIFA World Cup qualifier against Sudan.
FIFA has decided against all games on the final matchday of the African Zone qualifying for South Africa 2010 kicking off simultaneously.
After Sudan's 3-1 victory over Chad, all four teams are still in contention in Group 10 of Africa's second qualifying round, with one game to play.