Nice beat Lille 1-0 but the visitors remain in the hunt for European football next season, while Rennes took down Lyon 2-0 and Toulouse held Marseille to a 2-2 draw.
Marseille winger and France international Mathieu Valbuena faces up to a month out of action after suffering a collarbone injury during his side's 1-0 Ligue 1 defeat at Lille.
Paris Saint-Germain remained unbeaten in their Ligue 1 campaign after a 2-0 win over Toulouse, while Marseille also logged a 2-0 win against Lorient and Nice edged Guingamp 1-0.
Belarus coach Georgy Kondratiev has played down his team's hopes of repeating the shock win they claimed against France during UEFA EURO 2012 qualifying, saying Les Bleus are "much stronger" now.
Paris Saint-Germain ended a 19-year wait for the French title when they were crowned Ligue 1 champions this term, clinching their third championship after previously topping the table in 1985/86 and 1993/94.
Spain's trip to France is among the eye-catching fixtures in Tuesday's European Zone FIFA World Cup qualifiers. FIFA.com previews the action.