FIFA.com examines Group E, in which European duo Switzerland and France will hope to push past American contenders Honduras and Ecuador.
Kim Bo-kyung's 91st-minute equaliser gave Cardiff City a hard-fought point in a 2-2 draw with Manchester United, while Manchester City dazzled on their return from the international break to see off Tottenham Hotspur 6-0.
Tottenham Hotspur began their 2013/14 English Premier League campaign with a 1-0 win over Crystal Palace, while Jose Mourinho marked his return to Stamford Bridge as Chelsea manager by beating Hull City 2-0.
FIFA.com wraps up another massive evening of European Brazil 2014 qualifying highlighted by a crucial win for world champions Spain on their trip to Paris, while Montenegro and England remain evenly poised after a hard-fought draw.
Andre Villas-Boas has challenged his Tottenham side to show they are capable of cutting it in the UEFA Champions League by beating Lyon in their UEFA Europa League clash tomorrow.
Last season's European champions Chelsea headline a quartet of English clubs harbouring UEFA Europa League dreams as the competition resumes with the Blues visiting Sparta Prague.