Everton manager David Moyes says an emotion-charged atmosphere made for a fitting farewell to Goodison Park ahead of his move to the Manchester United hot-seat.
Rio Ferdinand scored his first goal in five years to lift Manchester United to a 2-1 victory over Swansea City in Sir Alex Ferguson's final match at Old Trafford, while Everton beat West Ham United 2-0 and Southampton drew 1-1 with Sunderland.
Shaun Maloney's late equaliser secured a point for Wigan Athletic at relegation rivals Queens Park Rangers, while Chelsea came from behind to beat Sunderland in Paolo Di Canio's first game in charge.
Manchester City put four past Newcastle United, while Chelsea stumbled at Southampton losing 2-1 and Manchester United edged Sunderland 1-0 to move even closer to clinch their 20th Premier League title.
Shinji Kagawa scored a hat-trick as Manchester United thrashed Norwich 4-0, while Harry Redknapp picked up three points on his 66th birthday to bring Queens Park Rangers to within four points of safety.
Goals from Kevin Mirallas, Leighton Baines and Leon Osman lifted Everton to a 3-1 home win over Oldham and into the FA Cup quarter-finals, with the pair having played out a 2-2 draw at Boundary Park 10 days ago.