Manchester United suffered a 2-1 loss at the hands of visitors Ajax in the second leg of the UEFA Europa League last-32 tie, however, a 2-0 win last week in Amsterdam ensured the Red Devils' progression.
Manchester United narrowly progressed to the UEFA Europa League last 16 with a 3-2 aggregate win over Ajax, while three La Liga sides in Valencia, Athletic Bilbao and Atletico Madrid also booked their place.
Ajax centre-back Toby Alderweireld has been ruled out for between two and four weeks with a hamstring strain, adding to an injury list that already includes Andre Ooijer, Kolbeinn Sigthorsson and Derk Boerrigter.
Ajax have confirmed that Kolbeinn Sigthorsson could be out until the Eredivisie winter break with an ankle injury the Icelandic striker suffered during their weekend defeat by FC Groningen.
A sensational second-half showing, and a wonder-strike from Toby Alderweireld, saw Ajax lead the Eredivisie after a 5-1 win over Heerenveen, while FC Utrecht fought back to claim a draw with De Graafschap.
Ajax cruised to a convincing 5-1 victory over Heerenveen, notably putting the game beyond doubt in the second half with three goals, at the Amsterdam Arena.