The most anticipated round of the campaign will unfold in the USA as six of the top seven square off in Brazil, while six teams will hope to finish the weekend as the outright leaders in Argentina.
A goal in each half saw Mexico's Guadalajara reach the Copa Libertadores final for the first time with the 3-1 aggregate win ending Universidad de Chile's hopes of a maiden final.
FIFA.com speaks exclusively to the talented Chivas defender, swiftly emerging as one of the key men in Sven-Goran Eriksson's side.
North, Central American and Caribbean Zone
Clint Dempsey's goal five minutes before half-time was enough to give the USA victory over Cuba in Havana in an historic qualifying encounter.
