European champions Bayern Munich and Manchester City both won to secure passage to the UEFA Champions League knockout stage, while Gareth Bale scored his first European goal for Real Madrid in a 2-2 draw with Juventus.
Ajax have sold midfielder Demy De Zeeuw to Spartak Moscow for a fee around €7m, with the Dutch international making his move after two years at the Amsterdam ArenA.
FC Twente remained on track to secure a league and cup double, after Marc Janko's extra-time header gave them a 3-2 edge over Ajax Amsterdam to claim the Dutch Cup.
Russian outfit Spartak Moscow eased into the quarter-finals of the UEFA Europa League with a dominant performance against Ajax Amsterdam tonight to complete a lopsided aggregate win.
The last 16 of the UEFA Champions League has been finalised with the final three spots secured by Arsenal, Roma and Shakhtar Donetsk who became the first Ukrainian club to win through in over a decade.
Demy de Zeeuw has called on Ajax to return to winning ways on Sunday against VVV-Venlo after a recent slump in form, while PSV Eindhoven go to NAC Breda as they look to keep their Eredivisie lead intact.