Led by Lionel Messi and John Obi Mikel, Argentina and Nigeria meet on the big stage yet again, while underdogs Iran and Bosnia-Herzegovina will hope to upset the odds.
Reigning CAF African Footballer of the Year Yaya Toure has once again been nominated for the award, with four Nigerians also among the shortlist.
Emmanuel Emenike scored twice as Nigeria came from behind to beat Ethiopia 2-1 in a closely-fought FIFA World Cup Africa zone play-off first leg, while great goalkeeping from Cameroon held Tunisia to a 0-0 draw.
John Obi Mikel's surprise strike at Stamford Bridge, the end of Barcelona's possession streak, a father-and-son duo at Tahiti 2013, a title in Iceland and a big Inter Milan win all feature in FIFA.com's latest stats review.
Jose Mourinho has discussed Juan Mata's reaction to not being in Chelsea's squad and challenged the Spaniard to use an upcoming League Cup game to make himself a first-choice player.
John Obi Mikel scored his first English Premier League goal in 185 appearances to take Chelsea to the top of the English Premier League table against cross-town rivals Fulham.