FIFA.com reviews the action from Groups E to H, with Chelsea the victims of the biggest upset, Borussia Dortmund crashing in Naples and Lionel Messi scoring a treble against Ajax.
Napoli served up a tough start for 2012/13 UEFA Champions League runners-up Borussia Dortmund, as the Italian side saw off the ten-man visitors 2-1 thanks to goals from Gonzalo Higuain and Lorenzo Insigne.
Edinson Cavani grabbed his 99th, 100th and 101st Napoli goals with an impressive hat-trick against Inter Milan. Ricky Alvarez had levelled after Cavani opened the scoring before the Uruguayan completed his treble.
Lionel Messi has been speaking about the tricky trip to face Bolivia in La Paz, while other players and coaches in the South American Zone have been assessing their chances.
FIFA.com recaps Friday’s four Brazil 2014 qualifiers in South America, which all went the way of the home sides, with Argentina taking over at the top of the group.
Despite trailing twice in the first half, Juventus roared back to beat nine-man Napoli 4-2 after extra time and lift the Italian Super Cup at the Bird's Nest stadium in Beijing.