Despite finishing with ten men, La Liga champions Barcelona fought back to beat Atletico Madrid 2-1, while Valencia downed Rayo Vallecano 4-0.
Lionel Messi came on on as a substituteand had an immediate impact for Barcelona, scoring twice as Barça beat Real Betis 4-2 in La Liga while Sevilla secured a 3-0 victory over Espanyol.
Despite a wonder goal from substitute Lionel Messi, Barcelona were held to a 2-2 draw at Athletic Bilbao, with Ander Herrera scoring a late equaliser for the hosts.
FIFA.com previews this week's UEFA Champions League quarter-final second legs, with big guns from Spain and Germany in pole position to advance after first-leg gains.
Chile host Uruguay in what looks set to be a crucial game in the hunt for an automatic South American FIFA World Cup™ qualification place, while leaders Argentina visit Bolivia and Colombia travel to Venezuela.
An Alexis Sanchez opener and a superb second from substitute Lionel Messi earned leaders Barcelona a 2-0 win over rock-bottom Deportivo at Camp Nou.