Cristiano Ronaldo was forced off with a slight thigh strain having opened the scoring and Gareth Bale was also on target as Real Madrid won 5-0 at Almeria, while a depleted Barcelona beat Granada 4-0 at the Camp Nou.
Argentina, Chile, Colombia and Ecuador qualified directly from the South American Zone, while Uruguay made it through via an intercontinental play-off. FIFA.com reviews the qualifiers.
Alexis Sanchez replicated the performance by former Chile captain Marcelo Salas by scoring both goals at Wembley in a 2-0 win over England as the South Americans saw off a much-changed Roy Hodgson side.
Alexis Sanchez's strike in the 68th minute was the difference in the derby that saw Barcelona best a feisty Espanyol side 1-0, moving Gerardo Martino's men to the top of La Liga.
Barcelona moved four points clear of Atletico Madrid at the top of La Liga as they eased to a 3-0 win over Celta Vigo, while Espanyol and Malaga battled to a scoreless draw.
Goals from Neymar and Alexis Sanchez led Barcelona to a 2-1 win at Camp Nou to move Gerardo Martino's side six points clear of their rivals at the top of La Liga.