Brazil will start the pool as the favourites, while Cameroon, Croatia and Mexico will all be hopeful in what is, on paper, a wide-open fight for a second spot in the knockout phase.
Following his midweek brace that led Manchester United to a 4-0 win over Norwich City in the League Cup, Mexico striker Javier Hernandez may have broken into David Moyes' starting XI against Fulham this weekend.
The all-star trio of Franck Ribery, Cristiano Ronaldo and Robin van Persie feature alongside Standard Liege and Buriram United in FIFA.com's latest stats review.
Chelsea triumphed 2-0 over Arsenal at the Emirates, while Fulham lost a seven-goal thriller at Leicester in the fourth round of the English League Cup.
Manchester United rediscovered their famous fighting spirit by coming from behind to beat Stoke City at Old Trafford, while Luis Suarez scored his first Anfield hat-trick against West Brom.
Honduras are favourites to seal the third and final direct qualifying spot for Brazil 2014, but Mexico, who have finally found form, might just have something to say about that on Tuesday.