Fresh from their record European defeat at home to Real Madrid, Schalke 04 face another massive challenge when they travel to high-flying Bayern Munich on Saturday.
Arsenal's reunion with Bayern Munich features among this week's last-16 ties, with Barcelona's trip to Manchester City another tie that is sure to set pulses racing. FIFA.com previews the action.
Second-placed Bayer Leverkusen broke their three-match losing streak with a 2-1 win at home to Stuttgart, while Schalke moved up to fourth in the Bundesliga table after beating Wolfsburg at home.
Bayern Munich were propelled to a 2-0 win over Eintracht Braunschweig by Arjen Robben's brace, Borussia Dortmund beat ten-man Mainz 3-1 and Werder Bremen battled Hoffenheim to a thrilling 4-4 draw.
11 teams can secure passage to the UEFA Champions League knockout phase this week, while five former winners of the European competition, including Juventus and Borussia Dortmund face an early exit if they fail to win.
Bayer Leverkusen grabbed a narrow 1-0 win away at Hertha Berlin to move, at least temporarily, into third place in the German Bundesliga, while Eintracht Frankfurt and Schalke played out an entertaining 3-3 draw.