Goals from Cristiano Ronaldo and Karim Benzema helped Real Madrid move top of the La Liga table for the first time since May 2012, while Levante won away to Sevilla.
Atletico Madrid and Barcelona were held to 1-1 draws with Sevilla and Levante respectively, missing out on an opportunity to create some distance at the top of the Spanish La Liga table as Villareal earned a 2-0 win over Almeria.
Levante have taken striker Robert Acquafresca on loan from Bologna and signed defender Loukas Vyntra on a free transfer.
Panathinaikos extended their lead at the top of the table to five points with a 1-0 win at 10-man Asteras Tripoli on an ill-tempered night of Greek football.
Panathinaikos went top of the table with a win away to struggling Levadiakos, as Asteras Tripoli emerged victorious in a 3-0 win over Giannina.