A 1-1 draw with Atlas gave Tijuana a three-point lead in the Mexican Apertura standings, while Monterrey climbed to third after beating bottom side Queretaro 3-2.
Tigres Monterrey eased past Atlante 2-1 to secure second place in the Apertura standings, while Christian Benitez grabbed a brace in Club America's 4-2 victory over Jaguares.
A late winner gave Santos Laguna the upper hand in their Clausura quarter-final play-off with a 4-3 win at Jaguares, while in the day's other game a single goal was enough for Tigres Monterrey to see off Morelia.
Arsenal and Penarol may be all but sure of places in the group stage, but El Nacional, Internacional, Real Potosi and Union Espanola will carry just one-goal leads into the seconds legs of their preliminary-round ties on away soil.
Toluca lead the way in the new Mexican Clausura season after coming from behind to beat Tigres Monterrey 2-1, while Atlante recorded their second victory by winning 2-1 at Puebla.
Two goals in the final seven minutes earned Jaguares a 2-2 draw against ten-man Santos Laguna in the first leg of their Apertura quarter-final, while Tigres Monterrey earned a 1-0 win at Pachuca.