There is a markedly Latin flavour to Group H, with Honduras, Chile and Spain pitted together. But it is not the first time the Spanish-speaking trio have locked horns in the pursuit of success.
Honduras appear to have plenty of work left to do in the final days before South Africa 2010 as they were held to a goalless draw by 10-man Azerbaijan
Honduras coach Reinaldo Rueda has left Noel Valladares, Ramon Nunez and Osman Chavez out of his squad for the friendly international against Turkey.
September's double fantasy matchdays provide a tough test for managers. In the first of two previews, FIFA.com looks at midfielder and forward selection.
While Costa Rica and the USA cool their jets with passage assured, Mexico face a tricky qualifying test in the Great White North in midweek.
Costa Rica, Mexico and USA can all guarantee their places in the final round of regional qualifying this weekend. FIFA.com takes a closer look.