Eden Ben Basat struck a late leveller as Israel drew in Portugal to all but end their hosts' chance of finishing top of Group F and delight Russia.
Basque rivals Real Sociedad and Athletic Bilbao both started their campaigns with victories while Valencia narrowly defeated Malaga at home in the opening matches of the 2013/14 La Liga season.
Real Madrid forced rivals Barcelona to delay their title celebrations as Cristiano Ronaldo hit his 200th goal for the club in an entertaining 4-3 win while neighbours Atletico Madrid drew 0-0 with Deportivo La Coruna.
Ten-man Real Madrid took down Rayo Vallecano 2-0, Atletico Madrid looked impressive in their 3-0 win over Real Valladolid, and Espanyol continued their recent winning ways with a 1-0 victory over Real Betis.
Tino Costa headed an injury time winner for Valencia in their 3-2 victory at Deportivo La Coruna on Saturday, with Levante also grabbing a stoppage time clincher earlier on.
Malaga narrowly defeated Valencia through a solitary goal from Nacho Camacho, which put them level on points with their visitors in third spot.