Arsenal capitalised on their numerical advantage when Steve Sidwell was sent off in the 12th minute to earn a 1-0 win at Fulham, while Queens Park Rangers and Reading both lost to further slip into the relegation zone.
Arsene Wenger admits Arsenal are in danger of failing to qualify for the UEFA Champions League for the first time in 16 years after the Gunners crashed to a 2-1 defeat at bitter rivals Tottenham.
Arsenal couldn't recover from two first half goals from Gareth Bale and Aaron Lennon, giving Tottenham Hotspur the three points from Sunday's north London derby.
AC Milan's reunion with southern European rivals Barcelona takes centre stage in the second set of first-leg fixtures in the UEFA Champions League Round of 16.
English Premier League sides will be seeking to survive the weekend's FA Cup round with a host of top flight clubs already eliminated. Manchester City against Leeds United and Oldham hosting Everton are among the highlights.
A massive weekend in the English Premier League is highlighted by a meeting of the top two as leaders Chelsea host second-placed Manchester United holding a four-point advantage.