Argentinian champions Velez Sarsfield were held to a goalless draw by compatriots Argentinos Juniors in their first-leg Copa Sudamericana tie, while Peru's Universitario won 2-1 at Venezuela's Anzoategui.
Santos Laguna maintained their 100 per cent record at the start of the Apertura competition with a 3-0 win at Pachuca.
Argentina avenged their defeat in the inaugural FIFA World Cup Final 79 years ago to qualify for South Africa and leave Uruguay facing a play-off.
Johan Fano scored and was then sent off as Peru ended a disappointing FIFA World Cup qualifying campaign on a high, beating Bolivia 1-0 in Lima.
A quintet of leagues recently ended with Bolivar, Caracas FC, Cerro Porteno, Universidad de Chile and Once Caldas atop their respective podiums.
Argentina, Chile and Uruguay were the big winners on Matchday 11, while Bolivia and Peru dropped out of contention and Brazil slipped to fourth.